News ID: 202118
Published: 0759 GMT October 10, 2017

Maternal smoking may lead to cerebral palsy in offspring

Maternal smoking may lead to cerebral palsy in offspring
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Smoking during pregnancy can be harmful for both mother and baby. Now, a new study provides further evidence that maternal smoking is a risk factor for cerebral palsy in offspring, and it has shed light on the mechanisms behind this association.

According to the Centers for Disease Control and Prevention (CDC), around 55 percent of mothers who smoke prior to becoming pregnant quit the habit during pregnancy, medicalnewstoday.com wrote.

However, around 10 percent of expectant mothers in the US still smoke in the final three months of pregnancy.

Smoking during pregnancy is a risk factor for numerous health problems among offspring, including premature birth, birth defects — such as cleft lip, or cleft palate — and sudden infant death syndrome.

Previous research has also linked maternal smoking with a greater likelihood of cerebral palsy in children, but the processes underlying this association have been unclear.

The new study — led by Dr. Hui Chen, of the University of Technology Sydney in Australia — teaches us more about the subject.

 

Cerebral palsy is a movement and balance disorder that is estimated to affect around one in 323 children in the US.

The condition is caused by damage to the developing brain. This may occur before birth, during birth, within one month of birth, or in a child's early years.

One cause of cerebral palsy is the brain being starved of oxygen-rich blood in the womb, a process known as hypoxia-ischemic injury (HII).

The new research — recently published in the journal Frontiers in Molecular Neuroscience — reveals how exposure to cigarette smoke in the womb can worsen responses to HII, causing cell death in brain regions associated with motor skills and memory, which are regions implicated in cerebral palsy.

The researchers came to their findings by studying mice born to mothers that had been exposed to cigarette smoke before and during pregnancy.

The team tested the motor skills of the mouse pups and found that they demonstrated movement problems similar to those that arise in cerebral palsy.

"We found that pups from smoking mothers are more clumsy at adolescent age, have less strength in their limbs, are more anxious, and have poor memory function which many affect their learning ability," said Chen.

On further investigation, the team found that the movement problems seen in the mouse pups were due to an increase in oxidative stress, which is the imbalance between antioxidants and harmful molecules called free radicals.

Chen explained that HII caused by cigarette smoke exposure prevents mitochondria — which are the ‘powerhouses’ of cells — from producing sufficient amounts of antioxidants, allowing free radicals to accumulate and cause damage to brain cells.

The researchers believe that findings provide yet another reason for expectant mothers to stop smoking, and they suggest that the earlier smoking is ceased, the better.

Chen said, "What we have observed so far is that in order to avoid harm to their baby, mothers need to give up smoking several months or even years before their pregnancy, as smoking will affect the quality of their eggs before they are even fertilized."

The team now plans to assess whether or not antioxidants could be used to reduce the harms of maternal smoke exposure among offspring; a previous study they conducted indicated that an antioxidant called L-carnitine improved kidney and respiratory function in mouse pups born to mothers exposed to cigarette smoke in pregnancy.

"The next step will be to use such a treatment to improve functional outcomes in pups from the smoking mothers," said Chen.

   
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