0105 GMT February 21, 2018
The international study was funded by Opdivo's maker, Bristol-Myers Squibb, and included more than 900 patients with stage III and stage IV melanoma, UPI wrote.
Patients were treated at 130 medical centers across 25 countries. All underwent surgery for their cancer before they began treatment with either Opdivo (nivolumab) or Yervoy (ipilimumab), the drug that's the current standard of care.
Both drugs are ‘immunotherapies’, which work by boosting the immune system's ability to spot and destroy tumor cells.
After a year of treatment, 71 percent of patients in the Opdivo group were alive without any recurrence of the disease, compared with 61 percent of those treated with Yervoy.
And at 18 months, the rate was 66 percent for Opdivo and 53 percent for Yervoy, the findings showed.
According to the Skin Cancer Foundation, metastatic melanoma accounts for only about one percent of skin cancer cases but causes the majority of skin cancer deaths.
Lead researcher Dr. Jeffrey Weber, professor of medicine at NYU School of Medicine, said, "Our results demonstrate that [Opdivo] is more effective in treating patients with stage III and IV melanoma, cutting the risk of relapse by a third.
"Results like this will change how we practice medicine. Hopefully, physicians will embrace the use of [Opdivo] in these high-risk patients as adjuvant therapy.”
One cancer surgeon who reviewed the findings was impressed.
Dr. Gary Deutsch, a surgical oncologist at Northwell Health's Imbert Cancer Center in Bay Shore, NY, said, "Based on this study, it appears that patients with advanced melanoma who have their disease completely removed by surgery should go on to receive additional therapy with Opdivo.
"Not only did these patients have a better survival outcome at one year, but they had only one-third the side effects compared to Yervoy.”
The study found that patients taking Opdivo had fewer severe side effects than those taking Yervoy, at 14 percent versus 45 percent.
Five percent of patients on Opdivo had to stop treatment due to side effects, compared with 31 percent of those on Yervoy.
The most common side effects for both drugs were fatigue and diarrhea.
Weber added that the safety of [Opdivo] is very promising.
Both Opdivo and Yervoy are already approved by the US Food and Drug Administration to treat advanced (metastatic) melanoma. In some patients, the drugs are used in combination.
Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City, said, “Any advance in the care of aggressive melanomas is welcome news for patients.
"It is amazing that there is now an alternative that is superior to conventional chemotherapy for advanced metastatic disease.
"With these advanced melanomas — that have high risks of recurrences and have poor outcomes — it is vital to look at alternative treatments. The future in cancer treatments lies in immunotherapy and other targeted options."